2026 USCAP Hematopathology Update

Videos+PDFs

Get access to the 2026 USCAP Hematopathology Update, a comprehensive educational course covering the latest diagnostic approaches to lymphoid and myeloid neoplasms, leukemia, lymphoma, bone marrow pathology, hematopoietic neoplasms, WHO 5th Edition classification, and International Consensus Classification (ICC).

Original Release Date: August 1, 2026
Official Course CME: 24 AMA PRA Category 1 Credits™
Format: Video Presentations + Course Documents/PDFs
Specialty: Pathology / Hematopathology / Hematology

This advanced hematopathology course brings together expert pathology faculty to review the morphologic diagnosis and modern classification of hematolymphoid disorders.

With molecular testing and next-generation sequencing becoming increasingly important in hematopathology, accurate morphologic interpretation remains fundamental for selecting appropriate ancillary studies and integrating molecular, immunophenotypic, cytogenetic and clinical findings into a final diagnosis.

The program provides extensive coverage of both lymphoid and myeloid pathology, with particular attention to applying the WHO Classification of Haematolymphoid Tumours, 5th Edition, and the International Consensus Classification (ICC) in everyday diagnostic practice.

Course Highlights

The 2026 USCAP Hematopathology Update covers:

• Reactive lymph node pathology
• Plasma cell neoplasms
• B-cell lymphomas
• T-cell lymphomas
• Hodgkin lymphoma
• Diffuse large B-cell lymphoma (DLBCL)
• Burkitt lymphoma
• Splenic and extranodal lymphomas
• Cutaneous lymphomas
• Acute myeloid leukemia (AML)
• Lymphoblastic leukemia/lymphoma
• Myelodysplastic neoplasms
• Myeloproliferative neoplasms
• MDS/MPN disorders
• Pediatric myeloid neoplasms
• Systemic mastocytosis
• Histiocytic and dendritic neoplasms
• Mixed phenotype acute leukemia
• Eosinophilic neoplasms
• Treated and progressed myeloid neoplasms
• Non-neoplastic bone marrow disorders
• WHO 5th Edition diagnostic criteria
• International Consensus Classification (ICC)
• Ancillary testing and molecular diagnostics
• Panel Q&A discussions

Complete 2026 USCAP Hematopathology Update Course Content

1. Reactive Lymph Nodes

Amy Chadburn, MD

Review reactive lymphadenopathies and important morphologic patterns that can mimic hematolymphoid neoplasia.

2. Plasma Cell Neoplasms

Robert Lorsbach, MD, PhD

Diagnostic evaluation and classification of plasma cell disorders and plasma cell neoplasms.

3. Bone Marrow B-Cell Lymphomas

Laurence L. de Leval, MD, PhD

Coverage includes:

CLL
Mantle Cell Lymphoma
Hairy Cell Leukemia
Splenic Marginal Zone Lymphoma
Lymphoplasmacytic Lymphoma
Small Lymphocytic Lymphoma
Richter Transformation

4. Follicular Lymphoma and Nodal Marginal Zone Lymphoma

Ioannis Anagnostopoulos, MD

Morphologic and diagnostic approach to follicular lymphoma and nodal marginal zone lymphoma.

5. Extranodal B-Cell Lymphomas and Splenic Lymphomas

Judith A. Ferry, MD

Diagnosis and classification of extranodal and splenic B-cell lymphoid neoplasms.

6. Burkitt and High-Grade Lymphoma / DLBCL

Amy Chadburn, MD

Detailed discussion of Burkitt lymphoma, high-grade B-cell lymphomas and diffuse large B-cell lymphoma.

7. The Many Other Faces of DLBCL

Judith A. Ferry, MD

Important variants and challenging presentations of diffuse large B-cell lymphoma.

8. Hodgkin Lymphoma and Related Entities

Ioannis Anagnostopoulos, MD

Current diagnostic criteria and differential diagnosis of Hodgkin lymphoma and related entities.

9. Immunodeficiency and Fluid-Based B-Cell Lymphomas

Amy Chadburn, MD

Hematolymphoid proliferations associated with immunodeficiency and fluid-based lymphoma entities.

10. Peripheral T-Cell Lymphoma #1

Laurence L. de Leval, MD, PhD

Diagnostic approach to peripheral T-cell lymphomas.

11. Peripheral T-Cell Lymphoma #2

Laurence L. de Leval, MD, PhD

Continued discussion of the classification, morphology and differential diagnosis of T-cell lymphoma.

12. Cutaneous T-Cell and B-Cell Lymphomas

Judith A. Ferry, MD

Diagnosis of primary cutaneous lymphoid neoplasms.

13. Non-Neoplastic Bone Marrow Conditions

Robert P. Hasserjian, MD

Morphologic evaluation of non-neoplastic and reactive bone marrow abnormalities.

14. Myeloproliferative Neoplasms

Daniel A. Arber, MD

Current classification and diagnostic criteria for myeloproliferative neoplasms.

15. Myelodysplastic Syndromes / Neoplasms and Clonal Cytopenias

Robert P. Hasserjian, MD

Updated approach to myelodysplastic neoplasms and clonal cytopenic disorders.

16. Pediatric Myeloid Neoplasms and Germline Conditions

Robert Lorsbach, MD, PhD

Pediatric myeloid malignancies and hereditary/germline predisposition disorders.

17. Acute Myeloid Leukemia

Joseph D. Khoury, MD

Modern classification and diagnosis of AML incorporating morphology, immunophenotyping and molecular findings.

18. B- and T-Lymphoblastic Leukemia/Lymphoma

Robert Lorsbach, MD, PhD

Diagnostic approach to B- and T-lineage lymphoblastic leukemia and lymphoma.

19. Histiocytic and Dendritic Neoplasms

Joseph D. Khoury, MD

Classification and differential diagnosis of histiocytic and dendritic-cell neoplasms.

20. Mixed Phenotype Acute Leukemias and Eosinophilic Neoplasms

Joseph D. Khoury, MD

Review of mixed phenotype acute leukemia and hematologic neoplasms associated with eosinophilia.

21. Systemic Mastocytosis

Daniel A. Arber, MD

Current diagnostic criteria and classification of systemic mastocytosis.

22. Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Daniel A. Arber, MD

Morphologic and molecular evaluation of overlapping myelodysplastic and myeloproliferative neoplasms.

23. Evaluation of Progressed and Treated Myeloid Neoplasms

Robert P. Hasserjian, MD

Evaluation of disease progression, treatment effects and post-treatment bone marrow findings.

24. Panel Q&A Sessions

Expert panel discussions addressing practical and challenging hematopathology cases.

Who Should Use This Course?

The 2026 USCAP Hematopathology Update is particularly useful for:

Practicing pathologists
Academic pathologists
Community pathologists
Hematopathologists
Pathology residents
Pathology fellows
Hematopathology fellows
Hematologists interested in diagnostic pathology
Physicians preparing for pathology board examinations or continuing certification

Learning Objectives

After completing the educational material, learners should have an improved understanding of how to:

• Recognize morphologic features of common and uncommon myeloid and lymphoid neoplasms.
• Differentiate neoplastic processes from reactive and non-neoplastic hematolymphoid proliferations.
• Apply WHO 5th Edition criteria to hematopoietic neoplasms.
• Apply International Consensus Classification (ICC) criteria.
• Approach cases where WHO and ICC classifications may produce different diagnoses.
• Select appropriate ancillary studies based on morphologic and clinical findings.
• Use ancillary testing efficiently and cost-effectively.
• Interpret molecular, immunophenotypic and other ancillary results.
• Integrate morphology, clinical findings and ancillary testing into a final diagnosis.

Major Topics Covered

Hematopathology • Hematolymphoid Pathology • Lymphoma • Leukemia • Bone Marrow Pathology • Acute Myeloid Leukemia • Myelodysplastic Neoplasms • Myeloproliferative Neoplasms • Plasma Cell Neoplasms • DLBCL • Burkitt Lymphoma • Hodgkin Lymphoma • T-Cell Lymphoma • B-Cell Lymphoma • Lymphoblastic Leukemia • Systemic Mastocytosis • WHO 5th Edition • ICC Classification • Molecular Hematopathology

Why This Course Is Important

Modern hematopathology increasingly incorporates advanced molecular technologies, including next-generation sequencing. However, morphology continues to serve as the foundation for accurate hematopathologic diagnosis.

Correct morphologic interpretation helps determine which ancillary investigations are necessary and allows pathologists to correctly interpret molecular, immunophenotypic and genetic findings.

This program therefore combines classic morphology with contemporary molecular and classification-based hematopathology, making it particularly useful for pathologists seeking an updated review of current diagnostic practice.

Course Information

Course: 2026 Hematopathology Update
Organization: United States and Canadian Academy of Pathology (USCAP)
Release Date: August 1, 2026
Content: Hematopathology educational presentations and accompanying course materials